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Genetic correction of sickle cell disease: Insights using transgenic mouse models

✍ Scribed by Trudel, Marie; Blouin, Marie-José; Beauchemin, Hugues; Wright, Adrian; De Paepe, Monique; Sorette, Martin; Bleau, Anne-Marie; Nakamoto, Betty; Ou, Ching-Nan; Stamatoyannopoulos, Georges

Book ID
109827545
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
345 KB
Volume
6
Category
Article
ISSN
1078-8956

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## Abstract Neurological complications such as stroke are known consequences of sickle cell disease (SCD). In order to improve methods for the evaluation of stroke risk in SCD, MRI was used to evaluate cerebrovascular function in transgenic mouse models of human SCD. It is hypothesized that oxygen‐