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Transgenic models to assess the pathogenic actions of cytokines in the central nervous system

✍ Scribed by Campbell, I L; Stalder, A K; Chiang, C-S; Bellinger, R; Heyser, C J; Steffensen, S; Masliah, E; Powell, H C; Gold, L H; Henriksen, S J

Book ID
110058757
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
88 KB
Volume
2
Category
Article
ISSN
1359-4184

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## Abstract Interleukin (IL)‐1Ξ² mediates diverse forms of neurodegeneration and exacerbates cell death induced by striatal injection of the excitotoxin α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid (AMPA) in the rat brain. The objective of this study was to determine whether this effect was