Varied actions of proinflammatory cytokines on excitotoxic cell death in the rat central nervous system

✍ Scribed by Stuart M. Allan

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 354 KB
• Volume: 67
• Category: Article
• ISSN: 0360-4012
• DOI: 10.1002/jnr.10142

✦ Synopsis

Abstract

Interleukin (IL)‐1β mediates diverse forms of neurodegeneration and exacerbates cell death induced by striatal injection of the excitotoxin α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid (AMPA) in the rat brain. The objective of this study was to determine whether this effect was specific to IL‐1β. Injection of IL‐1α and AMPA in the striatum had effects identical to those of IL‐1β, whereas coinjection of IL‐6 or tumor necrosis factor (TNF)‐α with AMPA failed to induce significant cortical cell death. In contrast to IL‐1α, IL‐1β, and IL‐6, TNFα significantly reduced (by 38%) the local striatal damage. These findings suggest that the effect of IL‐1 on AMPA receptor‐mediated cell death in the rat striatum is not mimicked by other proinflammatory cytokines. Furthermore, TNFα shows neuroprotective effects against acute excitotoxic injury. © 2002 Wiley‐Liss, Inc.