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Transgenic BACE expression in mouse neurons accelerates amyloid plaque pathology

✍ Scribed by M. H. Mohajeri; K. D. Saini; R. M. Nitsch

Book ID
106206575
Publisher
Springer
Year
2004
Tongue
English
Weight
475 KB
Volume
111
Category
Article
ISSN
1435-1463

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## Abstract We measured tissue distribution and expression pattern of the beta‐site amyloid precursor protein (APP)‐cleaving enzyme (BACE) in the brains of transgenic Tg2576 mice that show amyloid pathology. BACE protein was expressed at high levels in brain; at lower levels in heart and liver; and