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Expression of β-secretase mRNA in transgenic Tg2576 mouse brain with Alzheimer plaque pathology

✍ Scribed by M Bigl; J Apelt; E.A Luschekina; C Lange-Dohna; S Roßner; R Schliebs

Book ID
117471103
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
758 KB
Volume
292
Category
Article
ISSN
0304-3940

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Neuronal and glial β-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology
✍ Steffen Roßner; Jenny Apelt; Reinhard Schliebs; J. Regino Perez-Polo; Volker Big 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 965 KB

## Abstract We measured tissue distribution and expression pattern of the beta‐site amyloid precursor protein (APP)‐cleaving enzyme (BACE) in the brains of transgenic Tg2576 mice that show amyloid pathology. BACE protein was expressed at high levels in brain; at lower levels in heart and liver; and