SJL/J mice were immunized with human PLP as well as encephalitogenic PLP peptides 139-151 and 178-191 and the resulting antibody responses examined for immunochemical specificity employing a panel of 17 synthetic PLP peptide ligands. All animals had demonstrable circulating titers of antibodies earl
Transgenic and Natural Mouse Models of Proteolipid Protein (PLP)-Related Dysmyelination and Demyelination
β Scribed by I.R. Griffiths; A. Schneider; J. Anderson; K-A. Nave
- Book ID
- 119941101
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 920 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1015-6305
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The most common cause of PelizaeusβMerzbacher (PMD) is due to duplication of the __PLP1__ gene but it is unclear how increased gene dosage affects PLP turnover and causes dysmyelination. We have studied the dynamics of PLP/DM20 in a transgenic mouse model of PMD with increased gene dosa
## Abstract Two types of interventions to remyelinate the adult demyelinated central nervous system were investigated in heterozygous transgenic mice overexpressing the proteolipid protein gene. 1) A cocktail of trophic factors, βTS1,β was directed toward the activation of the endogenous pool of ne
The gene plp on the X chromosome encodes the isoforms proteolipid protein (PLP) and DM 20 , two dominant integral membrane proteins of central nervous system (CNS) myelin. DM 20 results from the activation of the cryptic splice site in exon III of the PLP gene. We inserted a sense-orientated loxP fl