Functional analysis in vivo of the double mutant mouse deficient in both proteolipid protein (PLP) and myelin basic protein (MBP) in the central nervous system

Rumpshaker-like proteolipid protein (PLP

Rumpshaker-like proteolipid protein (PLP) ratio in a mouse model with unperturbed structural and functional integrity of the myelin sheath and axons in the central nervous system

✍ Thomas Uschkureit; Olaf Spörkel; Heinrich Büssow; Wilhelm Stoffel 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 233 KB 👁 1 views

The gene plp on the X chromosome encodes the isoforms proteolipid protein (PLP) and DM 20 , two dominant integral membrane proteins of central nervous system (CNS) myelin. DM 20 results from the activation of the cryptic splice site in exon III of the PLP gene. We inserted a sense-orientated loxP fl