Synthesis of 9-(2-phosphonylmethoxy)ethy
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U. J. Haynes; J. E. Swigor; J. J. Bronson
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Article
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1992
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John Wiley and Sons
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French
β 153 KB
## Abstract The synthesis of [^14^C] PMEA (3) was achieved by coupling the sodium salt of 8β[^14^C]adenine (1) with 2β(diisopropylβphosphonymethoxy) ethanol methanesulfonate in N,Nβdimethylformamide at 100Β°C to provide the diisopropyl ester (2). Deesterification with bromotrimethylsilane in acetoni