Synthesis of C 14 -Labeled Guanine, Adenine, 8-Azaguanine and 8-Azaadenine 1
✍ Scribed by Bennett, Edward L.
- Book ID
- 121507628
- Publisher
- American Chemical Society
- Year
- 1952
- Tongue
- English
- Weight
- 359 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0002-7863
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📜 SIMILAR VOLUMES
## Abstract The synthesis of the title compounds [^14^C]‐PMEG (5) and [^14^c]‐EPMG (6) are described. Treatment of [^14^C]guanine with acetic anhydride in 1‐methyl‐2‐pyrrolidinone gave [^14^C]N‐acetylguanine (2). Reaction with 2‐(diethylphosphonomethoxy) ethylmethanesulfonate in N,N‐dimethylformami
## Abstract The synthesis of [^14^C] PMEA (3) was achieved by coupling the sodium salt of 8‐[^14^C]adenine (1) with 2‐(diisopropyl‐phosphonymethoxy) ethanol methanesulfonate in N,N‐dimethylformamide at 100°C to provide the diisopropyl ester (2). Deesterification with bromotrimethylsilane in acetoni