𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Transforming growth factor(TGF)-β1 induces leukemic cell-growth-promoting activity in fibroblast cells.

✍ Scribed by K. Komatsu; H. Nakamura; H. Akedo

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
362 KB
Volume
17
Category
Article
ISSN
1065-6995

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The production of the leukemic cell‐growth‐promoting factor (LGF) in TGF‐β1‐treated fibroblast cells was studied. BALB/c3T3 mouse fibroblast(3T3) cells cultured in Eagle's medium containing a low concentration of TGF‐β1 (0.04‐1 ng/ml) secreted 3‐5 times more LGF than the cells cultured in the absence of TGF‐β1. The amount of LGF secretion was dose‐dependent on the concentration of post‐cultured medium and time‐dependent after the addition of TGF‐β1. Similar findings were obtained in human diploid fibroblasts, WI‐38 cells. LGF is a 18KD glycoprotein that is acid‐stable but heat‐unstable.

📜 SIMILAR VOLUMES

Hyaluronic acid modulates gene expressio
Hyaluronic acid modulates gene expression of connective tissue growth factor (CTGF), transforming growth factor-β1 (TGF-β1), and vascular endothelial growth factor (VEGF) in human fibroblast-like synovial cells from advanced-stage osteoarthritis in vitro
✍ Yu-Tsang Lee; Hung-Jen Shao; Jyh-Horng Wang; Haw-Chang Liu; Sheng-Mou Hou; Tai-H 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 275 KB

Intraarticular injection of hyaluronan (hyaluronic acid; HA) is the common way to treat osteoarthritis (OA) of knees. This treatment cannot only maintain the viscoelastic properties of knee but also release the OA pain. However, the exact molecular mechanism is unknown. In this study, after human sy

Active transforming growth factor-β in h
Active transforming growth factor-β in human melanoma cell lines: No evidence for plasmin-related activation of latent TGF-β
✍ Jozef Bizik; Diana Felnerova; Marta Grofova; Antti Vaheri 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 929 KB

Cultured human melanoma cells were found to secrete TGF-P mostly in latent biologically inactive form but in addition five of six melanoma cell lines studied produced in conditioned culture medium active TGF-p in the range from 370 to 61 0 pg per 1 O6 cells per 24 h. A distinct characteristic of the

Transforming growth factor-β1 induces ap
Transforming growth factor-β1 induces apoptosis in gastric cancer cells through a p53-independent pathway
✍ Manabu Yamamoto; Yoshihiko Maehara; Yoshihisa Sakaguchi; Tetsuya Kusumoto; Yuji 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 579 KB

## BACKGROUND. Apoptosis is induced by various anticancer agents or radiation through the tumor suppressor gene p53-dependent pathway and is also induced by other factors, including transforming growth factor-PI (TGF-0,). In this study, the authors investigated whether TGF-0, would induce apoptosi

Endoglin negatively regulates transformi
Endoglin negatively regulates transforming growth factor β1-induced profibrotic responses in intestinal fibroblasts
✍ J. P. Burke; R. W. G. Watson; J. J. Mulsow; N. G. Docherty; J. C. Coffey; Profes 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 198 KB 👁 1 views

## Abstract ## Background Fibroblasts isolated from strictures in Crohn's disease (CD) exhibit reduced responsiveness to stimulation with transforming growth factor (TGF) β1. TGF-β1, acting through the smad pathway, is critical to fibroblast-mediated intestinal fibrosis. The membrane glycoprotein,