✦ LIBER ✦

Transforming growth factors and related peptides in gastrointestinal neoplasia

✍ Scribed by Robert J. Coffey; Carol M. McCutchen; Ramona Graves-Deal; William H. Polk Jr.

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 784 KB
Volume: 50
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.240501120

No coin nor oath required. For personal study only.

✦ Synopsis

Transforming growth factor a and 01 (TGFa and TGF 01) are representative members of two distinct and expanding families of polypeptide growth factors. TGFa is an epithelial cell mitogen, whereas TGFBl inhibits epithelial cell growth; the role of these factors in contributing to the transformed phenotype is uncertain. Steady state mRNA expression for these growth factors and their receptors in a panel of human colon cancers and adjacent normal mucosa is presented. Based in part on results from transgenic mice in which TGFa is selectively overproduced in the mammary gland, a possible role for TGFa as a tumor promoter in the process of transformation is discussed.

📜 SIMILAR VOLUMES

Cripto: a novel epidermal growth factor

Cripto: a novel epidermal growth factor (EGF)-related peptide in mammary gland development and neoplasia

✍ David S. Salomon; Caterina Bianco; Marta De Santis 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 243 KB 👁 1 views

Growth and morphogenesis in the mammary gland depend on locally derived growth factors such as those in the epidermal growth factor (EGF) superfamily. Cripto-1 (CR-1, human; Cr-1, mouse)-also known as teratocarcinoma-derived growth factor-1-is a novel EGF-related protein that induces branching morph

Expression of transforming growth factor

Expression of transforming growth factor-α and epidermal growth factor receptor in gastrointestinal stromal tumours

✍ Yun-Cai Cai; Zhong Jiang; Frank Vittimberga; Xiaowen Xu; L. Savas; Bruce Woda; M 📂 Article 📅 1999 🏛 Springer 🌐 English ⚖ 267 KB

Levels of transforming growth factor β a

Levels of transforming growth factor β and transforming growth factor β receptors in rat liver during growth, regression by apoptosis and neoplasia

✍ Bettina Grasl-Kraupp; Walter Rossmanith; Branislav Ruttkay-Nedecky; Leonhard Mül 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 500 KB

Transforming growth factor β 1 (TGF-β 1 ) has been implicated as inhibitor of cell proliferation and a potent inducer of apoptosis in vitro and in vivo after the administration of high doses. To assess the role of endogenous TGF-β 1 , we quantitated the cytokine and its receptors in rat liver during

Epidermal growth factor–related transfor

Epidermal growth factor–related transforming growth factors in the urine of patients with hepatocellular carcinoma

✍ Ph.D. Lea-Yea Chuang; Juei-Hsiung Tsai; Yun-Chi Yeh; Chun-Chang Chang; Hsing-Wu 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 472 KB

To characterize epidermal growth factor-related transforming growth factors in the urine of patients with hepatocellular carcinoma, gel filtration with Bio-Gel P-30 was performed in seven hepatocellular carcinoma patients and seven sex-matched and agematched healthy controls. Distinct profiles of so

Epidermal growth factor-related peptides

Epidermal growth factor-related peptides and the epidermal growth factor receptor in normal and malignant prostate

✍ E. R. Sherwood; C. Lee 📂 Article 📅 1995 🏛 Springer-Verlag 🌐 English ⚖ 831 KB

Epidermal growth factor (EGF) and transforming growth factor-alpha (TGFo0 are two closely related peptides that interact with cell-surface epidermal growth factor receptors (EGFR) to induce receptor tyrosine phosphorylation and activation of intracellular signal-transduction pathways. EGF appears to

Transforming growth factor-β1 and fibrob

Transforming growth factor-β1 and fibroblast growth factors in rat growth plate

✍ S. Jingushi; S. P. Scully; M. E. Joyce; Y. Sugioka; M. E. Bolander 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 965 KB

## Abstract Chondrocytes in the growth plate progress in an orderly fashion from resting through proliferating to hypertrophic cells. In the region of hypertrophic chondrocytes, the cartilage is invaded by capillary loops and endochondral ossification is initiated. It is currently believed that gro