Transforming growth factor-β1 (tgf-β1)-induced increase in ace and ace-like activity in cardiac fibroblasts
✍ Scribed by P Lijnen; V Petrov; R Fagard R
- Book ID
- 117987162
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 159 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0895-7061
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## Abstract The production of the leukemic cell‐growth‐promoting factor (LGF) in TGF‐β1‐treated fibroblast cells was studied. BALB/c3T3 mouse fibroblast(3T3) cells cultured in Eagle's medium containing a low concentration of TGF‐β1 (0.04‐1 ng/ml) secreted 3‐5 times more LGF than the cells cultured
Transforming growth factor b1 (TGF-b1) belongs to a family of multifunctional modulatory proteins involved in cell growth, differentiation, development, and wound healing. Although the biological activities of TGF-b1 have been extensively studied, its regulation remains obscure. Here we report the e