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Transforming growth factor β1 selectively regulates ornithine decarboxylase gene expression in malignant H-ras transformed fibrosarcoma cell lines

✍ Scribed by Robert A. R. Hurta; Arnold H. Greenberg; Jim A. Wright

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
912 KB
Volume
156
Category
Article
ISSN
0021-9541

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✦ Synopsis

Negative growth regulators such as the transforming growth factor beta (TGF-P) family appear to be important inhibitors in most tissue types. However, inhibition of DNA synthesis and cell proliferation is frequently lost during malignant transformation, and in some cases, tumor cell proliferation is actually stimulated by TGF-P. The present study demonstrates a novel link between alterations in TGF-P regulation during malignant conversion, and the expression of ornithine decarboxylase, a key rate-limiting activity in the biosynthesis of polyamines, and an enzyme that plays an important role in cell growth and differentiation. A panel of radiation and H-ras transformed mouse 10T% cell lines exhibiting increasing malignant potential was investigated for possible TGF-P, mediated changes in ornithine decarboxylase gene expression. Selective induction of gene expression was observed since only H-ras transformed cell lines with malignant potential exhibited marked elevations in ornithine decarboxylase message levels. Ornithine

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