## Background: A balance between urokinase-type plasminogen activator (upa) and its main inhibitor type-1 (pai-1) appears to be important for cancer invasive behavior. since upa/pai-1 system seems to be regulated by transforming growth factor beta1 (tgfbeta1) in different cell types, our aim was to
Transforming growth factor-β1 is a potent inducer of plasminogen activator inhibitor type-1 in human glioblastoma and carcinoma cell lines
✍ Scribed by Eirik Helseth; Are Dalen; Geirmund Unsgaard; Toril Skandsen; Jan GrØNdahl-Hansen; Leif R. Lund
- Book ID
- 114822464
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 584 KB
- Volume
- 96
- Category
- Article
- ISSN
- 0365-5555
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In the human glioblastoma cell line, T-MG1, plasminogen activator activity (PA-activity) was demonstrated by using the chromogenic substrate S-2251. Using monoclonal antibodies against human urokinase type PA (u-PA) and human tissue type PA (t-PA), only u-PA activity was found in T-MG1 cell extracts
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The transforming growth factors type PI, p2, and p,.2 suppress multidrug transport in human pat-1 glioblastoma cells and even in cells that strongly overexpress mdr genes and are resistant to inhibition of multidrug transport by chemosensitizers. Thus, inhibition of multidrug transport by cytokines