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Multidrug transport in human glioblastoma cells is inhibited by transforming growth factors type β1, β2, and β1.2

✍ Scribed by Ph.D. H. J. Schluesener

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
377 KB
Volume
28
Category
Article
ISSN
0360-4012

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✦ Synopsis

The transforming growth factors type PI, p2, and p,.2 suppress multidrug transport in human pat-1 glioblastoma cells and even in cells that strongly overexpress mdr genes and are resistant to inhibition of multidrug transport by chemosensitizers. Thus, inhibition of multidrug transport by cytokines might be a new approach to increase cellular accumulation of chemotherapeutic agents in multidrug resistant glial tumor cells. Interestingly, a member of the more distantly related decapentaplegic subgroup of transforming growth factors, the bone morphogenetic protein BMP 2, did not inhibit multidrug transport. Key words: glioblastoma, transforming growth factor type p, human pat-1 glioblastoma cells

MATERIALS AND METHODS Cytofluorometry of Multidrug Transport

Human glioblastoma cell lines pat-1 and pat-1 .mdr have been described previously (Schluesener and Meyermann, 1990). Cells were cultured in DMEM containing 5 % fetal calf serum. For analysis of multidrug transport,

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