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Transforming Growth Factor-β : Major Role in Regulation of Extracellular Matrix

✍ Scribed by ANITA B. ROBERTS; URSULA I. HEINE; KATHLEEN C. FLANDERS; MICHAEL B. SPORN

Book ID
119864189
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
516 KB
Volume
580
Category
Article
ISSN
0890-6564

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REGULATION OF EXTRACELLULAR MATRIX PROTE
REGULATION OF EXTRACELLULAR MATRIX PROTEINS BY TRANSFORMING GROWTH FACTOR β1IN CULTURED PULMONARY ENDOTHELIAL CELLS
✍ Gouri Shanker; Dan Olson; Roger Bone; Rajinder Sawhney 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 372 KB

Transforming growth factor beta-1 (TGF-1 ), which is present in lung tissue, has been suggested to play a role in modulating vascular cell function in vivo. The action of TGF-1 in vivo, especially at the local site of application to connective tissue, is anabolic and leads to pulmonary fibrosis and