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Transforming growth factor β exerts opposite effects from interleukin-1β on cultured rabbit articular chondrocytes through reduction of interleukin-1 receptor expression

✍ Scribed by F. Réadini; A. Mauviel; S. Pronost; G. Loyau; J.-P. Pujol


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
725 KB
Volume
36
Category
Article
ISSN
0004-3591

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The effects of IL-1 p and TGF-P on the biosynthesis of extracellular matrix structural components relative to the metalloproteinases and their inhibitor TlMPl in human articular chondrocytes were investigated. It has been proposed that TGFp, acting as a positive regulator of matrix accretion, can co