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Transforming growth factor-beta type II receptor confers tumor suppressor activity in murine renal carcinoma (renca) cells

✍ Scribed by Jason D Engel; Shilajit D Kundu; Tony Yang; Sharon Lang; Shannon Goodwin; Lynn Janulis; Jin Seon Cho; Jay Chang; Seong-Jin Kim; Chung Lee

Book ID: 117265944
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 581 KB
Volume: 54
Category: Article
ISSN: 0090-4295
DOI: 10.1016/s0090-4295(99)00093-x

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## Abstract Although dysregulation of transforming growth factor‐β (TGF‐β) signaling is implicated in renal carcinogenesis, its precise mechanism is unknown in renal cell carcinoma (RCC). In our study, we investigated Smad‐mediated TGF‐β signaling pathway and its regulatory mechanisms in surgical s