Transformations of β-d-xylofuranosyl nucleosides. Synthesis of 3′-azido-3′-deoxythymidine
✍ Scribed by A. G. Mustafin; R. R. Gataullin; I. B. Abdrakhmanov; L. V. Spirikhin; G. A. Tolstikov
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 154 KB
- Volume
- 47
- Category
- Article
- ISSN
- 1573-9171
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## Abstract New approaches to the synthesis of 3′‐azido‐3′‐deoxythymidine labelled with tritium in the heterocyclic base have been developed. With this aim, enzymatic transribosylation with [^3^H]thymine using the enzyme preparation from rat liver and a three‐step chemical synthesis with use of the
## Abstract The α,β‐unsaturated D‐sugar aldehyde 2, prepared from tri‐__O__‐acetyl‐D‐glucal, was converted into 1‐__O__‐acetyl‐3‐azido‐2,3‐dideoxy‐α‐D‐__arabino__‐pyranose (3) by reaction with sodium azide in a mixture of acetic acid and water followed by acetylation. Reaction of 3 with silylated p