Transformation of the product set in separation sequence synthesis
β Scribed by Yi-Ming Chen; L. T. Fan
- Publisher
- American Institute of Chemical Engineers
- Year
- 1991
- Tongue
- English
- Weight
- 298 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0001-1541
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**The mixture of homologous nucleotide fragments** usually formed during carrierβoligonucleotide synthesis can be separated chromatographically so as to isolate the desired fragment, if the latter is protected at the 5β²βend with a hexadecyloxytrityl group (see __(2)__ in the previous communication).
In conventional metathetical reactions, product separation is based on solubility product differences, and the resulting products are often impure and require purification by recrystallization. A new approach to product separation is described that relies on the formation of an unstable, volatile by