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Transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma of the parotid gland is independent of p53 mutations

✍ Scribed by Claudia Gedlicka; Chike B. Item; Markus Wögerbauer; Helga Martinek; Gregor Heiduschka; Boban M. Erovic; Matthaeus Ch.Grasl; Dietmar Thurnher


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
74 KB
Volume
101
Category
Article
ISSN
0022-4790

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The remainder of the examination is unremarkable. Fine-needle aspiration of the mass confirms pleomorphic adenoma which is consistent with the pathology of the original tumor.

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## Abstract ## Background. Pleomorphic adenoma constitutes the most common benign parotid gland tumor. Local recurrence after surgical treatment (lateral or total parotidectomy) has been described in 1% to 5% of cases. Malignant degeneration has been reported in 2% to 9% of cases of pleomorphic ad

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## Abstract ## Background Surgery for recurrent parotid pleomorphic adenoma is a challenging problem. ## Methods One hundred eight patients who underwent 134 reoperations for recurrent parotid pleomorphic adenoma (follow‐up, 22 years) were evaluated for histopathologic features and risk factors

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## Abstract ## Background Surgical management of recurrent pleomorphic adenoma of the parotid gland has a considerable risk of facial nerve injury and a high re‐recurrence rate. To obtain more insight into this issue we evaluated our experiences. ## Methods Medical records and histologic materia