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Transformation of normal human cells in the absence of telomerase activation

✍ Scribed by Yvette R. Seger; Marta Garcı́a-Cao; Sara Piccinin; Crocifissa Lo Cunsolo; Claudio Doglioni; Marı́a A. Blasco; Gregory J. Hannon; Roberta Maestro

Book ID
114413241
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
582 KB
Volume
2
Category
Article
ISSN
1535-6108

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## BACKGROUND. Telomerase activation is thought to be crucial for the continued growth or progression of cancer cells. Three major subunits of human telomerase, human telomerase RNA (hTR), telomerase-associated protein (TP1), and human telomerase catalytic subunit (hTERT) have been identified rece