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Regulation of telomerase activity in quiescent immortalized human cells

โœ Scribed by Wolfram Klapper; Kumud K. Singh; Klaus Heidorn; Reza Parwaresch; Guido Krupp

Book ID
114148354
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
188 KB
Volume
1442
Category
Article
ISSN
0167-4781

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Human telomerase, a ribonucleoprotein that adds TTAGGG repeats onto telomeres and compensates for their shortening, is repressed in most normal human somatic cells. Human somatic cells are considered to have a limited proliferation capacity because of the telomere shortening. Although immortalizatio