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Transformation of NIH 3T3 cells by a human c-sis cDNA clone

✍ Scribed by Clarke, Michael F.; Westin, Eric; Schmidt, David; Josephs, Steven F.; Ratner, Lee; Wong-Staal, Flossie; Gallo, Robert C.; Reitz, Marvin S.

Book ID
109734985
Publisher
Nature Publishing Group
Year
1984
Tongue
English
Weight
561 KB
Volume
308
Category
Article
ISSN
0028-0836

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Malignant transformation of NIH 3T3 fibr
Malignant transformation of NIH 3T3 fibroblasts by human c-sis is dependent upon the level of oncogene expression
✍ Linda H. Macarthur; Michael F. Clarke; Eric H. Westin πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 996 KB

## Abstract High‐level expression of the c‐__sis__ oncogene, which encodes the Ξ² chain of platelet‐derived growth factor, transforms immortalized rodent fibroblasts in vitro to a malignant phenotype. c‐__sis__ gene expression has been demonstrated in a variety of human tumors, although generally at