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Transferrin receptors and iron uptake during erythroid cell development

โœ Scribed by B.J. Iacopetta; E.H. Morgan; G.C.T. Yeoh

Book ID
115725889
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
565 KB
Volume
687
Category
Article
ISSN
0005-2736

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Belgrade (b) rats have an autosomal recessive, microcytic, hypochromic anemia. Transferrin (Tf)-dependent iron uptake is defective because of a mutation in DMT1 (Nramp2), blocking endosomal iron efflux. This experiment of nature permits the present study to address whether the mutation also affects