𝔖 Bobbio Scriptorium
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Transferrin receptor expression by human bladder transitional cell carcinomas

✍ Scribed by Seymour, G.J. ;Walsh, M.D. ;Lavin, M.F. ;Strutton, G. ;Gardiner, R.A.

Publisher
Springer
Year
1987
Tongue
English
Weight
520 KB
Volume
15
Category
Article
ISSN
0300-5623

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✦ Synopsis

The expression of transferrin receptors (TFR) by normal and neoplastic urothelial cells was studied in "control" patients and in patients with transitional cell carcinoma of the bladder. These tumours were graded independently and consisted of 19 grade I, 30 grade II and 19 grade III lesions. TFRs were identified using a monoclonal antibody specific for TFR (OKT9) in an immunofluorescent or avidin/biotin-immunoperoxidase technique on fresh frozen sections. TFRs were not detected on normal urothelium. However, positive staining was found to increase with increasing pathological grade and stage of the tumours, ranging from 31.6% of grade I to 78.9% of grade III tumours and 51.2% of pTa (mucosa only lesions) to 87.5% of pT2/pT2+ (muscle invasion +/- deeper) primary urothelial malignancies.

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