Transfection with Fluorinated Lipoplexes Based on New Fluorinated Cationic Lipids and in the Presence of a Bile Salt Surfactant

Improved in vitro gene transfer mediated

Improved in vitro gene transfer mediated by fluorinated lipoplexes in the presence of a bile salt surfactant

✍ Jérôme Gaucheron; Catherine Santaella; Pierre Vierling 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 199 KB

Background Progress in the field of gene transfer with non-viral vectors requires systems that allow efficient gene expression in the presence of biological fluids such as pulmonary surfactants, for gene transfer to the respiratory epithelium for cystic fibrosis gene therapy, or bile salts (which co