## Abstract ## Objective Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with established roles in a range of inflammatory conditions. However, it is not known whether MIF influences inflammation via the direct promotion of leukocyteโendothelial cell interactions. Theref
Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice
โ Scribed by David P. Andrew; Jason P. Spellberg; Hiroaki Takimoto; Rudolf Schmits; Tak W. Mak; Mark M. Zukowski
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 198 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0014-2980
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LFA-1 on the surface of encephalitogenic T cells has been suggested to be involved in the pathogenesis of experimental autoimmune encephalomyelitis. By applying a novel technique of intravital fluorescence microscopy that enables us to visualize the interaction of circulating encephalitogenic T lymp
Interleukin-1b converting enzyme (ICE) processes the inactive proIL-1b to the proinflammatory mature IL-1b. ICE belongs to a family of cysteine proteases that have been implicated in apoptosis. To address the biological functions of ICE, we generated ICE-deficient mice through gene targeting technol