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TRANSCRIPTIONAL SILENCING OF THE sFRP2 GENE BY EPIGENETIC MECHANISMS IN RENAL CELL CARCINOMA

✍ Scribed by Kawamoto, Ken; Hirata, Hiroshi; Kikuno, Nobuyuki; Tanaka, Yuichiro; Nakagawa, Masayuki; Dahiya, Rajvir

Book ID: 123088063
Publisher: Lippincott Williams and Wilkins
Year: 2008
Tongue: English
Weight: 132 KB
Volume: 179
Category: Article
ISSN: 0022-5347
DOI: 10.1016/S0022-5347(08)60265-7

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## Abstract The soluble frizzled receptor protein (__SFRP__) family encodes antagonists of the WNT pathway, and silencing of these genes, through promoter hypermethylation, leads to constitutive WNT signaling. In bladder cancers, hypermethylation of the __SFRP__ genes occurs more often in current a