Transcriptional repression of the testis-specific histone H1t gene mediated by an element upstream of the H1/AC box
β Scribed by Steven A. Wolfe; Sidney R. Grimes
- Book ID
- 117521301
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 486 KB
- Volume
- 308
- Category
- Article
- ISSN
- 0378-1119
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The testis-specific histone H1t is synthesized during spermatogenesis exclusively in late pachytene primary spermatocytes. Transcription of the H1t gene is repressed in every tissue except testis. Within the testis, transcription is repressed during development before the spermatocyte stage and in l
The rat testis-specific linker histone H1t gene is transcribed in pachytene primary spermatocytes during spermatogenesis. Our previous work using transgenic mice demonstrated that spermatocyte-specific transcription of the H1t gene is dependent upon a proximal promoter element designated the TE elem
## Abstract Transcription of the mammalian testisβspecific linker histone __H1t__ gene occurs only in pachytene primary spermatocytes during spermatogenesis. Studies of the wild type (Wt) and mutant H1t promoters in transgenic mice show that transcription of the __H1t__ gene is dependent upon the T
## Abstract The Xβbox binding protein RFX4 is highly expressed in testis in contrast with other tissues, but its function there is unknown. Another family member abundant in testis, RFX2, has been shown to bind to the XβBox elements in the promoter of the testis specific histone H1t, which is expre