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Transcriptional activation of α1(III) procollagen gene in Tsk2/+ dermal fibroblasts

✍ Scribed by Paul J Christner; Tatyana Yufit; Josephine Peters; Rodney McGrath; Raymond F Conway; Sergio A Jiménez


Book ID
117053530
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
241 KB
Volume
303
Category
Article
ISSN
0006-291X

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Interferon-␥ (IFN-␥), a multifunctional cytokine produced by activated Th1 lymphocytes, exerts potent effects on the extracellular matrix by regulating fibroblast function. In this study, we examined the modulation of ␣1(I) procollagen gene (COL1A1) expression by recombinant IFN-␥. The results showe