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Exposure of human dermal fibroblasts to a fibrin gel matrix downregulates α1(I) procollagen transcription

✍ Scribed by Crane, Saara; Zhou, Linda; Yamaguchi, Yuji; Ochoa, Sofia; Badiavas, Evangelos; Falanga, Vincent


Book ID
119562122
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
178 KB
Volume
16
Category
Article
ISSN
0923-1811

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Decreased levels of alpha 1(I) procollag
✍ Jeffrey B. Pardes; Hajime Takagi; Theresa A. Martin; M. Sofia Ochoa; Vincent Fal 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 570 KB

We have investigated human neonatal fibroblast synthetic activity in response to fibrin substrates and components of fibrin formation and degradation. Greater than threefold downregulation of procollagen mRNA levels was seen 24 hours after fibroblasts were grown on fibrin gels as compared to tissue