Transcriptional activation of the human gastrin-releasing peptide receptor gene in gastrointestinal and prostatic epithelial cancer cells
โ Scribed by Xiangping Qu; Dongmei Xiao; H. Christian Weber
- Book ID
- 111639716
- Publisher
- Humana Press Inc
- Year
- 2004
- Tongue
- English
- Weight
- 209 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0895-8696
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BACKGROUND. Bombesin-like peptides can function as autocrine or paracrine growth factors and stimulate the growth of some cancer cells, including human prostate cancer. Three bombesin receptor subtypes, termed gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMBR), and bombesin rece
## Abstract The binding of ^125^IโTyr^4^ bombesin was investigated on plasma membranes of 8 human breast cancer cell lines and 2 longโterm cultures of normal human breast epithelial cells. Scatchard plots were compatible with highโaffinity, singleโsite class of receptors in 3 cell lines (K~D~ of 0.