Transcriptional activation of adipogenesis
β Scribed by Zhidan Wu; Pere Puigserver; Bruce M Spiegelman
- Book ID
- 114309632
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 97 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0955-0674
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The recent discovery of lipid-activatable transcription factors that regulate the genes controlling lipid metabolism and adipogenesis has provided insight into the way that organisms sense and respond to lipid levels. Identification of the signaling pathways in which these receptors are involved wil
## Abstract Prostaglandin F2Ξ± (PGF2Ξ±) is a potent paracrine inhibitor of adipocyte differentiation. Here we show that treatment of differentiating 3T3βL1 preadipocytes with PGF2Ξ± induces the expression of DEC1, a transcriptional repressor that has previously been implicated in the inhibition of adi