𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Peroxisome proliferator activated receptors: transcriptional regulators of adipogenesis, lipid metabolism and more…

✍ Scribed by W. Wahli; O. Braissant; B. Desvergne

Book ID
103997310
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
706 KB
Volume
2
Category
Article
ISSN
1074-5521

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✦ Synopsis

The recent discovery of lipid-activatable transcription factors that regulate the genes controlling lipid metabolism and adipogenesis has provided insight into the way that organisms sense and respond to lipid levels. Identification of the signaling pathways in which these receptors are involved will help us to understand the control of energy balance and the molecular defects underlying its disorders.

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Abbreviations: HSC, hepatic stellate cells; ␣-SMA, ␣ smooth muscle actin; PDGF, platelet-derived growth factor; PPAR␥, peroxisome proliferator-activated receptor ␥; 9-cisRA, 9-cis retinoic acid; RXR, retinoic X receptor; 15d-PGJ 2 , 15-deoxy-⌬ 12,14 prostaglandin J 2 ; [ 3 H]TdR, [methyl-3 H]thymidi