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Transcriptional activation and increase in expression of Alzheimer's β-amyloid precursor protein gene is mediated by TGF-β in normal human astrocytes

✍ Scribed by Teralee Burton; Binhua Liang; Alex Dibrov; Francis Amara


Book ID
117052196
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
553 KB
Volume
295
Category
Article
ISSN
0006-291X

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Both neural and nonneural human tissues from patients with or without Alzheimer's disease (AD) were surveyed to detect the presence of the P-amyloid protein and its precursors. This was accomplished using polyclonal and monoclonal antibodies to epitopes in the 695 amino acid long p-APP (i.e., P-APPm