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MicroRNA-101 downregulates Alzheimer’s amyloid-β precursor protein levels in human cell cultures and is differentially expressed

✍ Scribed by Justin M. Long; Debomoy K. Lahiri


Book ID
116301220
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
615 KB
Volume
404
Category
Article
ISSN
0006-291X

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One of the pathological lesions in Alzheimer's disease (AD) is the amyloid or senile plaque. The plaque core is predominantly made up of amyloid beta peptide (AP), a 42-43 amino acid peptide derived from amyloid precursor protein (APP). APP is a membrane bound glycoprotein which is expressed ubiquit