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Transcription of the LAT gene is regulated by multiple binding sites for Sp1 and Sp3

✍ Scribed by Caitlyn Whitten; Sarah Swygert; Sara E. Butler; Timothy S. Finco

Book ID: 116508013
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 711 KB
Volume: 413
Category: Article
ISSN: 0378-1119
DOI: 10.1016/j.gene.2008.01.020

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## Abstract The transcription factors Sp1, Sp3, and Egr‐1 bind with their zinc finger DNA‐binding domains to GC‐rich sequences in the regulatory regions of their target genes. The similarity of the DNA‐binding sites of Sp1, Sp3, and Egr‐1 has triggered the hypothesis that they compete for the same