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Transcription of biliary glycoprotein I gene in malignant and non-malignant human liver tissues

✍ Scribed by Yuji Hinoda; Kohzoh Imai; Naoaki Nakagawa; Yumiko Ibayashi; Tatsumi Nakano; Raymond J. Paxton; John E. Shively; Akira Yachi

Publisher: John Wiley and Sons
Year: 1990
Tongue: French
Weight: 439 KB
Volume: 45
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910450516

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✦ Synopsis

Biliary glycoprotein I (BGP I) is a member of carcinoembryonic antigen (CEA) gene family consisting of at least I I related genes. The transcription of BGP I gene was analysed in mali nant and non-malignant human liver tissues with a 396-bp 9'-untranslated region probe from a cDNA clone 4-I3 which was newly isolated from an adult human colon cDNA library. Among 21 tissue samples from I 4 patients with hepatocellular carcinoma, 16 samples were clearly shown to express a single 3.9-kb message. This message was also found in the hepatoma cell line HUH-7. When the malignant tissues were compared to the non-malignant ones for the intensity of the band, no significant difference was observed. mRNAs of CEA and non-specific cross-reacting antigen (NCA) were not detected in 5 samples which were shown to have the message of the BGP I gene. These data suggest that the human hepatocyte and its malignant transformant produce BGP I, and that this could correspond to the cross-reacting antigen previously detected in the liver.

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