Malignant melanoma: relationship of the human leukocyte antigen Class II gene DQB1*0301 to disease recurrence in American Joint Committee on Cancer Stage I or II
✍ Scribed by Jeffrey E. Lee; Meisheng Lu; Paul F. Mansfield; Chris D. Platsoucas; John D. Reveille; Merrick I. Ross
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 576 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
✦ Synopsis
BACKGROUND.
Melanoma patients who carry the human leukocyte antigen (HLA) Class I1 allele DQLll*0301 have an increased frequency of metastases at presentation compared with those lacking HLA-DQB1*0301. This study was designed to determine whether HLA-DQBI*0301 is associated with an increased risk of recurrence in melanoma patients presenting with American Joint Committee on Cancer (AJCC) Stage I or 11 (localized) disease.
METHODS.
Molecular oligotyping of HLA-DQ genes was performed for 259 patients with AJCC Stage I or I1 melanoma. Rate of disease recurrence was determined by retrospective review and prospective follow-up. Kaplan-Meier analysis, log rank, and proportional hazard (Cox) comparison were performed.