✦ LIBER ✦

Transcription factors drive B cell development

✍ Scribed by James Hagman; Kara Lukin

Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 297 KB
Volume: 18
Category: Article
ISSN: 0952-7915
DOI: 10.1016/j.coi.2006.01.007

No coin nor oath required. For personal study only.

✦ Synopsis

Transcription factors including PU.1, E2A and early B cell factor (EBF) are essential for the earliest stages of B lymphocyte development. Recent advances suggest that, although PU.1 initiates events leading to B lymphopoiesis, it might be dispensable at later stages of development. E2A proteins are also crucial for B cell lineage determination, as shown by the pluripotency of E2A-deficient progenitors. Both PU.1 and E2A are required for expression of EBF. EBF activates the early program of genes unique to B cells, including the lineage commitment factor Pax5. EBF also facilitates the function of Pax5 by mediating epigenetic changes necessary for the function of Pax5 at gene targets. Together, these proteins function in a hierarchy of factors that orchestrates B cell development.

📜 SIMILAR VOLUMES

Expression of transcription factors duri

Expression of transcription factors during oligodendroglial development

✍ Michael Wegner 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 139 KB

## Abstract Transcription factors coordinate the orderly changes of gene expression that underlie all developmental processes including those of oligodendrocytes. In comparison to other systems, relatively little is known about the role of transcription factors during oligodendrocyte development. H

Identification of uniquely expressed tra

Identification of uniquely expressed transcription factors in highly purified B-cell lymphoma samples

✍ Ulrika Andréasson; Patrik Edén; Carsten Peterson; Carl-Magnus Högerkorp; Mats Je 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 504 KB

Delivering transcription factors to cont

Delivering transcription factors to control stem cell fate

📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 42 KB

Transcription factors that control devel

Transcription factors that control development of the thymic microenvironment

✍ Thomas Boehm; Michael Nehls; Bruno Kyewski 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 381 KB

B-cell development

✍ Norman R. Klinman; Dwane E. Wylie; Judy M. Teale 📂 Article 📅 1981 🏛 Elsevier Science 🌐 English ⚖ 497 KB

Transcriptional control during T-cell de

Transcriptional control during T-cell development

✍ Hans Clevers; Pierre Ferrier 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 586 KB

During the past few years, the essential role of distinct transcription factors in specifying cell-fate decisions in a stepwise fashion during T-cell differentiation has been revealed. One striking feature is that a single factor can act at several sites throughout T-cell development, possibly throu