✦ LIBER ✦

Transcriptional control during T-cell development

✍ Scribed by Hans Clevers; Pierre Ferrier

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 586 KB
Volume: 10
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(98)80245-8

No coin nor oath required. For personal study only.

✦ Synopsis

During the past few years, the essential role of distinct transcription factors in specifying cell-fate decisions in a stepwise fashion during T-cell differentiation has been revealed. One striking feature is that a single factor can act at several sites throughout T-cell development, possibly through interactions with different partners. The challenge is now to understand how these interactions can account for the co-ordination of complex extracellular signals and gene expression programs, such as those involved in T-cell receptor gene recombination and expression.

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