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Transcription activity is required for p53-dependent tumor suppression

✍ Scribed by Gaidarenko, O; Xu, Y


Book ID
109971088
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
418 KB
Volume
28
Category
Article
ISSN
0950-9232

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## Abstract p53 is a sequence‐specific DNA‐binding transcription factor and key regulator of cell cycle arrest and apoptosis. p53 is mutated in most human cancers and these mutations generally impair its ability to activate transcription. When expressed in __Saccharomyces cerevisiae__, p53 acts as