Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans
✍ Scribed by R.M. Guéant-Rodriguez; C. Rendeli; B. Namour; L. Venuti; A. Romano; G. Anello; P. Bosco; R. Debard; P. Gérard; M. Viola; E. Salvaggio; J.L. Guéant
- Book ID
- 117473924
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 78 KB
- Volume
- 344
- Category
- Article
- ISSN
- 0304-3940
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Folic acid administration to women in the periconceptional period reduces the occurrence of neural tube defects (NTDs) in their offspring. A polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR), 677C¨T, is the first genetic risk factor for NTDs in man identified at the molec
## Abstract ## BACKGROUND A 28‐bp repeat polymorphism in the 5′UTR of the thymidylate synthase (__TYMS__) gene represents a candidate risk factor for neural tube defects (NTDs) due to involvement in folate‐dependent homocysteine metabolism. Non‐Hispanic, white, U.S. citizens carrying at least one