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Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association

✍ Scribed by Valerie B. O’Leary; James L. Mills; Faith Pangilinan; Peadar N. Kirke; Christopher Cox; Mary Conley; Andrea Weiler; Kun Peng; Barry Shane; John M. Scott; Anne Parle-McDermott; Anne M. Molloy; Lawrence C. Brody

Book ID
116987620
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
252 KB
Volume
85
Category
Article
ISSN
1096-7192

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## Abstract ## BACKGROUND A 28‐bp repeat polymorphism in the 5′UTR of the thymidylate synthase (__TYMS__) gene represents a candidate risk factor for neural tube defects (NTDs) due to involvement in folate‐dependent homocysteine metabolism. Non‐Hispanic, white, U.S. citizens carrying at least one