Trans-signaling by cytokine and growth factor receptors
β Scribed by Alexander M. Castellino; Moses V. Chao
- Book ID
- 117757802
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 813 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1359-6101
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The role of membrane receptors is regarded as being to transduce the signal represented by ligand binding from the external cell surface across the membrane into the cell. Signals are subsequently conveyed from the cytoplasm to the nucleus through a combination of second-messenger molecules, kinase/
The JAK/STAT pathway is recognized as one of the major mechanisms by which cytokine receptors transduce intracellular signals. This system is regulated at multiple levels, including JAK activation, nuclear trafficking of STAT factors, and negative feedback loops. Gene deletion studies have implicate