✦ LIBER ✦

JAK/STAT signaling by cytokine receptors

✍ Scribed by Kathleen D Liu; Sarah L Gaffen; Mark A Goldsmith

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 712 KB
Volume: 10
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(98)80165-9

No coin nor oath required. For personal study only.

✦ Synopsis

The JAK/STAT pathway is recognized as one of the major mechanisms by which cytokine receptors transduce intracellular signals. This system is regulated at multiple levels, including JAK activation, nuclear trafficking of STAT factors, and negative feedback loops. Gene deletion studies have implicated selected STAT factors as predominant mediators for a limited number of lymphokines. This signaling pathway influences normal cell survival and growth mechanisms and may contribute to oncogenic transformation.

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