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trans -4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: A New Class of Potent and Selective 5-HT 1A Receptor Ligands as Conformationally Constrained Analogues of 4-[3-(5-Methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1- arylpiperazines

✍ Scribed by Perrone, Roberto; Berardi, Francesco; Colabufo, Nicola A.; Leopoldo, Marcello; Lacivita, Enza; Tortorella, Vincenzo; Leonardi, Amedeo; Poggesi, Elena; Testa, Rodolfo


Book ID
127045409
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
164 KB
Volume
44
Category
Article
ISSN
0022-2623

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2-[4-(o-methoxyphenyl)piperazin-1-ylmeth
✍ MarΓ­a L. LΓ³pez-RodrΓ­guez; MaJosΓ© Morcillo; MaLuisa Rosado; Bellinda Benhamu; Ant πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 246 KB

A series of 2-[~-(4-arylpiperazin-1-yl)aikyl]-1,3-dioxoperhydroimidazo[ 1,5-a]pyridine derivatives was prepared and evaluated for affinity at 5-HT~A and ct I receptors. The most promising analogue Ira bound at 5-HT~A sites with nanomolar affinity (/~.=31.7) and high selectivity over ~, D2 and 5-HT2A