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TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype

✍ Scribed by Monzur Rahman; Sean R. Davis; Janet G. Pumphrey; Jing Bao; Marion M. Nau; Paul S. Meltzer; Stanley Lipkowitz


Publisher
Springer US
Year
2008
Tongue
English
Weight
815 KB
Volume
113
Category
Article
ISSN
0167-6806

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## Abstract Focal adhesion kinase, FAK is a 125 kDa nonreceptor tyrosine kinase that localizes to focal adhesions. FAK is overexpressed in human tumors and regulates cellular adhesion and survival signaling. We have shown previously that the dominant‐negative FAK, C‐terminal FAK‐CD, caused detachme