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TRAIL-induced apoptosis of human melanoma cells involves activation of caspase-4

✍ Scribed by Zhi Gang Mao; Chen Chen Jiang; Fan Yang; Rick F. Thorne; Peter Hersey; Xu Dong Zhang

Publisher
Springer
Year
2010
Tongue
English
Weight
706 KB
Volume
15
Category
Article
ISSN
1360-8185

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## Abstract Melanoma is the most lethal form of human skin cancer. However, only limited chemotherapy is currently available for the metastatic stage of the disease. Since chemotherapy, radiation and sodium arsenite treatment operate mainly through induction of the intrinsic mitochondrial pathway,